Eli Lilly to Conduct Additional Study of Alzheimer’s Drug





The drug maker Eli Lilly & Company said on Wednesday that it planned an additional study of an experimental Alzheimer’s drug that failed to improve the condition of people with the disease, saying that it remained hopeful about the drug’s prospects.




The newest study is expected to get under way in the third quarter of 2013 and will focus on patients with mild Alzheimer’s disease. Lilly released results of two clinical trials in August that showed the drug, called solanezumab, did not significantly improve either the cognition or the daily functioning of people with mild and moderate forms of the disease. But despite that failure, the results also gave some reason for hope: when patients with mild Alzheimer’s were separated out, the drug was shown to significantly slow their decline in cognition.


In a statement on Wednesday, the company said it decided not to pursue approval of the drug based on existing study results after it met with officials from the Food and Drug Administration. A Lilly executive said, however, that the company was still optimistic.


“We remain encouraged and excited by the solanezumab data,” David Ricks, a senior vice president at Lilly and president of Lilly Bio-Medicines, said in the statement. “We are committed to working with the F.D.A. and other regulatory authorities to bring solanezumab to the millions of patients and caregivers suffering from this devastating disease who urgently need this potential treatment.”


The Lilly drug is the second Alzheimer’s treatment to fail in clinical trials this year. Pfizer and Johnson & Johnson stopped development of a similar treatment, bapineuzumab, after it, too, was not shown to work. Both drugs target beta amyloid, a protein in the brain that is found in people with Alzheimer’s disease.


Lilly shares closed at $49, down 3.2 percent.


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State of the Art: Google Maps App for iPhone Goes in the Right Direction - Review





It was one of the biggest tech headlines of the year: in September, Apple dropped its contract with Google, which had always supplied the data for the iPhone’s Maps app. For various strategic reasons, Apple preferred to write a new app, based on a new database of the world that Apple intended to assemble itself.




As everybody knows by now, Apple got lost along the way. It was like a 22-car pileup. Timothy Cook, Apple’s chief executive, made a quick turn, publicly apologizing, firing the executive responsible and vowing to fix Maps. For a company that prides itself on flawless execution, it was quite a detour.


Rumors swirled that Google would create an iPhone app of its own, one that would use its seven-year-old, far more polished database of the world.


That was true. Today, Google Maps for the iPhone has arrived. It’s free, fast and fantastic.


Now, there are two parts to a great maps app. There’s the app itself — how it looks, how it works, what the features are. In this regard, few people complain about Apple’s Maps app; it’s beautiful, and its navigation mode for drivers is clear, uncluttered and distraction-free.


But then there’s the hard part: the underlying data. Apple and Google have each constructed staggeringly complex databases of the world and its roads.


The recipe for both companies includes map data from TomTom, satellite photography from a different source, real-time traffic data from others, restaurant and store listings from still more sources, and so on. In the end, Apple says that it incorporated data from at least 24 different sources.


Those sources always include errors, if only because the world constantly changes. Worse, those sources sometimes disagree with one another. It takes years to fix the problems and mesh these data sources together.


So the first great thing about Google’s new Maps is the underlying data. Hundreds of Google employees have spent years hand-editing the maps, fixing the thousands of errors that people report every day. (In the new app, you report a mistake just by shaking the phone.) And since 2006, Google’s Street View vehicles have trawled 3,000 cities, photographing and confirming the cartographical accuracy of five million miles of roads.


You can sense the new app’s polish and intelligence the minute you enter your first address; it’s infinitely more understanding. When I type “200 W 79, NYC,” Google Maps drops a pin right where it belongs: on the Upper West Side of Manhattan.


Apple’s Maps app, on the other hand, acts positively drunk. It asks me to clarify: “Did you mean 200 Durham Road, Madison, CT? Or 200 Madison Road, Durham, CT?”


Um, what?


And then there’s the navigation. Lots of iPhone owners report that they’ve had no problem with Apple’s driving instructions, and that’s great. But I’ve been idiotically misdirected a few times — and the trouble is, you never know in advance. You wind up with a deep mistrust of the app that’s hard to shake. Google’s directions weren’t great in the app’s early days either, and they’re still not always perfect. But after years of polishing and corrections, they’re right a lot more often.


The must-have features are all here: spoken driving directions, color-coded real-time traffic conditions, vector-based maps (smooth at any size). But the new app also offers some incredibly powerful, useful features that Apple’s app lacks.


Street View, of course, lets you see a photograph of a place, and even “walk” down the street in any direction. Great for checking out a neighborhood before you go, scoping out the parking situation or playing “you are there” when you read a news article.


Along with driving directions, Google Maps gives equal emphasis to walking directions and public transportation options.


This feature is brilliantly done. Google Maps displays a clean, step-by-step timeline of your entire public transportation adventure. If you ask for a route from Westport, Conn., to the Empire State Building, the timeline says: “4:27 pm, Board New Haven train toward Grand Central Terminal.” Then it shows you the names of the actual train stops you’ll pass. Then, “5:47 pm, Grand Central. Get off and walk 2 min.” Then, “5:57 pm, 33rd St: Board the #6 Lexington Avenue Local towards Brooklyn Bridge.” And so on.


Even if public transportation were all it did, Google Maps would be one of the best apps ever. (Apple kicks you over to other companies’ apps for this information.)


E-mail: pogue@nytimes.com



This article has been revised to reflect the following correction:

Correction: December 13, 2012

An earlier version of this column misstated the type and, because of an editing error, the number of businesses for which interior views are available. It is 100,000, not 100, and the number includes many kinds of businesses, not just restaurants. An earlier version of a caption described a feature of the app incorrectly. When navigating, users can swipe green banner on the screen to look ahead at the next written driving instruction; it is not possible to swipe ahead to coming turns.



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'Lincoln,' 'Les Mis,' 'Playbook' lead SAG awards


LOS ANGELES (AP) — The Civil War saga "Lincoln," the musical "Les Miserables" and the comic drama "Silver Linings Playbook" boosted their Academy Awards prospects Wednesday with four nominations apiece for the Screen Actors Guild Awards.


All three films were nominated for overall performance by their casts. Also nominated for best ensemble cast were the Iran hostage-crisis thriller "Argo" and the British retiree adventure "The Best Exotic Marigold Hotel."


Directed by Steven Spielberg, "Lincoln" also scored individual nominations for Daniel Day-Lewis in the title role as best actor, Sally Field for supporting actress as Mary Todd Lincoln and Tommy Lee Jones for supporting actor as abolitionist firebrand Thaddeus Stevens.


"Les Miserables," from "The King's Speech" director Tom Hooper, had nominations for Hugh Jackman for best actor as Victor Hugo's long-suffering hero Jean Valjean and Anne Hathaway for supporting actress as a woman fallen into prostitution, plus a nomination for its stunt ensemble.


"Silver Linings Playbook," made by "The Fighter" director David O. Russell, also had lead-acting nominations for Bradley Cooper and Jennifer Lawrence as lost souls who find a second chance at love and Robert De Niro for supporting actor as a football-obsessed dad.


Besides Lawrence, best-actress nominees are Jessica Chastain as a CIA analyst pursuing Osama bin Laden in "Zero Dark Thirty"; Marion Cotillard as a woman who finds romance after tragedy in "Rust and Bone"; Helen Mirren as Alfred Hitchcock's strong-willed wife in "Hitchcock"; and Naomi Watts as a woman caught in the devastation of a tsunami in "The Impossible."


Joining Cooper, Day-Lewis and Jackman in the best-actor field are John Hawkes as a polio victim aiming to lose his virginity in "The Sessions" and Denzel Washington as a boozy airline pilot in "Flight."


SAG nominees are almost all familiar names in Hollywood's awards season. Eighteen of the 20 film acting contenders are past Academy Awards nominees and 13 have won Oscars, among them five two-time winners. Only Cooper and Jackman have never before earned Oscar nominations.


One of the year's most-acclaimed films, Paul Thomas Anderson's "The Master," earned only one nomination, supporting actor for Philip Seymour Hoffman as a mesmerizing cult leader. The film was snubbed on nominations for ensemble, lead actor Joaquin Phoenix and supporting actress Amy Adams.


Other individual performances overlooked by SAG voters include Anthony Hopkins in the title role of "Hitchcock," Keira Knightley in the title role of "Anna Karenina," Bill Murray as Franklin Roosevelt in "Hyde Park on Hudson" and "Argo" director Ben Affleck, who also starred in the film.


The SAG Awards will be presented Jan. 27. The guild nominations are one of Hollywood's first major announcements on the long road to the Feb. 24 Oscars Awards, whose nominations will be released Jan. 10.


Nominations for the Golden Globes, the second-biggest film honors after the Oscars, come out Thursday.


Maggie Smith had four individual and ensemble nominations. Along with sharing the ensemble honor for "Best Exotic Marigold Hotel," Smith joined the cast of "Downton Abbey" among TV ensemble contenders and had nominations for supporting film actress as a cranky retiree in "Marigold Hotel" and TV drama actress for "Downton Abbey."


Nicole Kidman earned two individual nominations, as supporting film actress as a woman smitten with a prison inmate in "The Paperboy" and best actress in a TV movie or miniseries as war correspondent Martha Gellhorn in "Hemingway & Gellhorn."


Bryan Cranston had three overall nominations, as best actor in a TV drama for "Breaking Bad," an ensemble honor for that show and a film ensemble honor for "Argo."


Along with "Breaking Bad" and "Downton Abbey," best TV drama ensemble contenders are "Boardwalk Empire," ''Homeland" and "Mad Men." TV comedy ensemble nominees are "30 Rock," ''The Big Bang Theory," ''Glee," ''Modern Family," ''Nurse Jackie" and "The Office."


___


Online:


http://www.sagawards.org


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Cheikh Modibo Diarra, Mali’s Prime Minister, Resigns After Arrest





BAMAKO, Mali — Soldiers arrested Mali’s prime minister at his residence late Monday night, signaling new turmoil in a West African nation racked by military interference and an Islamist takeover in the north.







Associated Press

Prime Minister Cheikh Modibo Diarra appeared on state television and announced his government’s resignation on Tuesday.







Hours later, Prime Minister Cheikh Modibo Diarra appeared grim-faced on national television to announce his government’s resignation. A spokesman for soldiers who seized power earlier in the year — and later nominally relinquished it to Mr. Diarra — confirmed the prime minister’s arrest on Tuesday morning, accusing him of “playing a personal agenda” while the country faced a crisis in the north. The soldiers arrived at Mr. Diarra’s home around 11 p.m. Monday as he was preparing for a flight to Paris for a medical checkup, said the military spokesman, Bakary Mariko. The prime minister was taken to the military encampment at Kati, just outside Bamako, the capital, where Capt. Amadou Sanogo, the officer who led the March military coup, and others told him “there were proofs against him that he was calling for subversion,” Mr. Mariko said.


On Tuesday morning, the streets of Bamako appeared calm following what appeared to be the country’s second coup d’état in less than a year. But the new upheaval is likely to be considered a setback to Western efforts to help Mali regain control of territory lost to Qaeda-linked militants earlier in the year.


The West has watched with growing alarm as Islamist radicals have constructed a stronghold in the country’s vast north. The United Nations, regional African bodies, France and the United States have tried to aid the faltering Malian Army in a military strike to take back the lost north. Those efforts have so far not coalesced into a coherent plan, despite numerous meetings and United Nations resolutions. More meetings at the United Nations are planned for later this month.


The latest political turmoil in the capital will almost certainly slow down any campaign in the north, however. Already, the United States has expressed reluctance to provide too much direct military assistance, given the shakiness of the political order here. Those doubts are only likely to increase following the latest upheaval.


Mr. Diarra — appointed last spring as a caretaker prime minister until new elections could be organized — was known to disagree with Captain Sanogo on military policy.


He has been an advocate of immediate international military assistance to recapture the north from the Islamists. Captain Sanogo has rebuffed suggestions that the Malian military is incapable of handling the job on its own. Indeed, the captain for weeks resisted the notion that troops from other African nations should even approach the capital.


While Mr. Diarra has made the rounds of foreign capitals, pleading for help to fight the increasingly aggressive Islamists, military leaders have remained at the Kati base, grumbling.


That conflict was evident in the declarations of the military’s spokesman on Tuesday. “Since he has been in power, he has been working simply to position his own family,” Mr. Mariko said. “There has been a paralysis in government.”


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Notorious patent troll hits RIM with new lawsuit, seeks BlackBerry sales ban






Well-known patent troll Wi-LAN has filed a new lawsuit against BlackBerry maker Research In Motion (RIMM) in the U.S. District Court for the Southern District of Florida. Wi-LAN, which describes itself as “a leading intellectual property licensing company,” claims RIM’s BlackBerry smartphones infringe U.S. Patent No. 6,260,168, owned by Wi-LAN, which relates to Bluetooth implementation. The lawsuit covers multiple BlackBerry handsets including Bold, Torch, Pearl and Storm models, Reuters reports. Wi-LAN is reportedly seeking unspecified damages and is looking to ban sales of RIM’s infringing BlackBerry phones in the United States.


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TNT: Funeral coming for J.R. Ewing on new 'Dallas'


NEW YORK (AP) — J.R. Ewing will get a send-off with a proper funeral on "Dallas."


TNT begins the second season of its "Dallas" revival next month. The network said Tuesday that it will hold a funeral for Larry Hagman's memorable character at some point in the 15-episode season but that it hasn't been filmed or scheduled yet. Hagman died at age 81 over the Thanksgiving weekend.


TNT spokeswoman Erin Felentzer says the network isn't saying how Ewing will be killed off in the series. Hagman kept working until soon before his death due to complications of cancer, and will appear in several of the new season's episodes.


Hagman's character is a television icon dating back to the "Who Shot J.R.?" episodes in the 1980s.


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Global Update: Hand-Held Device Locates Hot Spots of Lead Contamination





Using a hand-held scanner to map hot spots where the soil is full of lead could protect children in mining towns against brain damage, scientists at Columbia University concluded in a new study.


Touched to the ground, the device, an X-ray fluorescence scanner,can measure the soil’s lead content in less than a minute, said Alexander van Geen, a geochemist at Columbia’s Lamont-Doherty Earth Observatory and an author of the study, which is in the current issue of the Bulletin of the World Health Organization. The “XRF guns,” which are often used by scrap-metal sorters, cost between $15,000 and $40,000.


His team tested the scanners in Cerro de Pasco, Peru, a town in the high Andes with mines dating back 1,400 years. Samples as close as 100 yards apart showed widely variable lead levels, so it is possible to find and mark off the areas most dangerous to young children, who get fine lead dust on their hands while playing and then put their fingers in their mouths.


“People assume the contamination is everywhere, and it’s not,” Dr. van Geen said. “It could be in one backyard and not in another.” Or, he said, in an untested playground, schoolyard, or any place where children gather.


The technology could be useful anywhere families live close to mines or smelters, which is common in Latin America and Africa, he said. Lead is a byproduct not just of lead mines, but of mining for gold, silver, copper and other metals.


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Barry Diller Sells TripAdvisor Shares



ENGLEWOOD, Colo. (AP) — Barry Diller is stepping down as chairman of TripAdvisor after selling his stake in the travel website to Liberty Interactive.


Liberty Interactive bought 4.8 million shares of TripAdvisor Inc.'s common stock from Diller and The Diller-von Furstenberg Family Foundation for a total of about $300 million, making it the travel website's new majority shareholder.


Shares of TripAdvisor jumped 8.2 percent to $41.55 in afternoon trading Tuesday.


Diller, a former Fox and Paramount executive, said that he's stepping down as chairman and selling his shares because he has other obligations to attend to.


Diller will remain a director at TripAdvisor, based in Newton, Mass. He also serves as chairman of IAC/InterActiveCorp.


Liberty spent $62.50 per share. It now owns and controls 18.2 million shares of TripAdvisor's common stock and 12.8 million shares of its Class B common stock. That's about 22 percent of the equity and 57 percent of the total votes of all classes of TripAdvisor common stock.


Greg Maffei, Liberty's president and CEO, called TripAdvisor a leader in the travel industry and said the increased investment in the company will be a strong addition to Liberty's portfolio.


Liberty Interactive Corp. owns shopping websites like the QVC shopping channel and also invests in other companies.


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Project Seeks to Map and Reduce Ocean Noise Pollution





When a hurricane forced the Nautilus to dive in Jules Verne’s “Twenty Thousand Leagues Under the Sea,” Captain Nemo took the submarine down to a depth of 25 fathoms, or 150 feet. There, to the amazement of the novel’s protagonist, Prof. Pierre Aronnax, no whisper of the howling turmoil could be heard.




“What quiet, what silence, what peace!” he exclaimed.


That was 1870.


Today — to the dismay of whale lovers and friends of marine mammals, if not divers and submarine captains — the ocean depths have become a noisy place.


The causes are human: the sonar blasts of military exercises, the booms from air guns used in oil and gas exploration, and the whine from fleets of commercial ships that relentlessly crisscross the global seas. Nature has its own undersea noises. But the new ones are loud and ubiquitous.


Marine experts say the rising clamor is particularly dangerous to whales, which depend on their acute hearing to locate food and one another.


To fight the din, the federal government is completing the first phase of what could become one of the world’s largest efforts to curb the noise pollution and return the sprawling ecosystem to a quieter state.


It is no small ambition: the sea covers more than 70 percent of the planet’s surface. But scores of the ocean visualizations have now been made public.


The federal effort seeks to document human-made noises in the ocean and transform the results into the world’s first large sound maps. The ocean visualizations use bright colors to symbolize the sounds radiating out through the oceanic depths, frequently over distances of hundreds of miles. Several of the larger maps present the sound data in annual averages — demonstrating how ages in which humans made virtually no contribution to ocean noise are giving way to civilization’s roar.


The overall purpose is to better understand the cacophony’s nature and its impact on sea mammals as a way to build the case for reductions.


“It’s a first step,” Leila T. Hatch, a marine biologist and one of the project’s two directors, said of the sound maps. “No one’s ever done it on this scale.”


The National Oceanic and Atmospheric Administration began the effort in 2010 at the behest of Jane Lubchenco, a prominent marine biologist who is the first woman to head the agency. Dr. Hatch and her colleagues assembled a team of sound experts, including HLS Research, a consulting firm in La Jolla, Calif. This summer, they unveiled their results on the Web, as did a separate team of specialists that sought to map the whereabouts of populations of whales, dolphins and porpoises.


Michael Jasny, a senior policy analyst with the Natural Resources Defense Council, a private group in New York that has sued the Navy to reduce sounds that can harm marine mammals, praised the maps as “magnificent” and their depictions of sound pollution as “incredibly disturbing.”


“We’ve been blind to it,” Mr. Jasny said in an interview. “The maps are enabling scientists, regulators and the public to visualize the problem. Once you see the pictures, the serious risk that ocean noise poses to the very fabric of marine life becomes impossible to ignore.”


Legal experts say the new findings are likely to accelerate efforts both domestically and internationally to deal with the complicated problem through laws, regulations, treaties and voluntary noise reductions.


The government already has some authority to regulate oceanic sound in United States waters through the Endangered Species Act and the Marine Mammal Protection Act, though exemptions to these laws exist for the military.


The International Maritime Organization, a United Nations body responsible for improving marine safety and reducing ship pollution, also has the authority to set acoustic standards. In the past few years, encouraged by the United States, it began discussing how to achieve voluntary noise reductions.


Since many commercial vessels are registered abroad, and most shipping noises arise in international waters, the organization’s backing is seen as crucial for reductions to be substantial enough to have global repercussions.


“Right now we’re talking about nonbinding guidelines,” said Michael Bahtiarian, an adviser to the United States delegation to the maritime organization and a senior official at Noise Control Engineering, a company outside Boston that specializes in reducing ship noise and vibrations. “At a minimum, the goal is to stop the increases.”


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RIM teases BlackBerry 10 launch with image of first BB10 smartphone






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