In Behind-Scene Blows and Triumphs, Sense of Clinton Future

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Secretary of State Hillary Rodham Clinton behind President Hamid Karzai of Afghanistan during a meeting in Germany in 2011.

WASHINGTON — Last summer, as the fighting in Syria raged and questions about the United States’ inaction grew, Secretary of State Hillary Rodham Clinton conferred privately with David H. Petraeus, the director of the C.I.A. The two officials were joining forces on a plan to arm the Syrian resistance.

The idea was to vet the rebel groups and train fighters, who would be supplied with weapons. The plan had risks, but it also offered the potential reward of creating Syrian allies with whom the United States could work, both during the conflict and President Bashar al-Assad’s eventual removal.

Mrs. Clinton and Mr. Petraeus presented the proposal to the White House, according to administration officials. But with President Obama in the midst of a re-election bid, they were rebuffed.

A year earlier, she had better luck with the White House. Overcoming the president’s skeptical aides, she persuaded Mr. Obama to open relations with the military rulers in Myanmar, a reclusive dictatorship eager to emerge from decades of isolation.

As she leaves the State Department, the simplest yardstick for measuring Mrs. Clinton’s legacy has been her tireless travels: 112 countries, nearly a million miles, 401 days on the road. Historians will point to how she expanded the State Department’s agenda to embrace issues like gender violence and the use of social media in diplomacy.

“We do need a new architecture for this new world: more Frank Gehry than formal Greek,” Mrs. Clinton said in a speech last week that served as both a valedictory and a reminder of why she remained the nation’s most potent political figure aside from Mr. Obama.

And yet, interviews with more than a dozen current and former officials also paint a more complex picture: of a dogged diplomat and a sometimes frustrated figure who prized her role as team player, but whose instincts were often more activist than those of a White House that has kept a tight grip on foreign policy.

The disclosures about Mrs. Clinton’s behind-the-scenes role in Syria and Myanmar — one a setback, the other a success — offer a window into her time as a member of Mr. Obama’s cabinet. They may also be a guide to her thinking as she ponders a future run for the presidency with favorability ratings that are the highest of her career, even after her last months at the State Department were marred by the deadly attack on the American mission in Benghazi, Libya.

“Secretary Clinton has dramatically changed the face of U.S. foreign policy globally for the good,” said Richard L. Armitage, deputy secretary of state during the George W. Bush administration. “But I wish she had been unleashed more by the White House.”

In an administration often faulted for its timidity abroad, “Clinton wanted to lead from the front, not from behind,” said Vali R. Nasr, a former State Department adviser on Afghanistan and Pakistan who is now the dean of the Johns Hopkins School of Advanced International Studies.

Mrs. Clinton made her first official trip to Asia, a choice that spoke to her diplomatic ambitions as well as her recognition from the start that many big-ticket foreign-policy issues in the Obama administration — Iraq, Iran, and peacemaking in the Middle East — would be controlled by the White House or the Pentagon.

In Afghanistan, several officials said, Mrs. Clinton hungered for a success on the order of the Dayton Accords, which ended the Bosnian War. But when her special representative, Richard C. Holbrooke, who had negotiated that agreement, fell out of favor with the White House and later died, those dreams died with him.

Then came the Arab awakening, a strategic surprise that eclipsed America’s pivot to focusing on Asia and plunged Mrs. Clinton into a maelstrom. It tested her loyalty to longtime allies like President Hosni Mubarak of Egypt and reinforced her conviction that anger at decades of stagnation, fueled by social media, would sweep aside the old order in the Arab world.

After Britain and France argued for intervening to defend Libya’s rebels against Colonel Muammar el-Qaddafi, Mrs. Clinton played an important role in mobilizing a broad international coalition and persuading the White House to join the NATO-led operation.

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Apple TV Is Running Late

So, Apple‘s big plan to talk cable companies into making the iPod of the television industry thus far involves getting Time Warner to let it put HBO Go on its box (if you buy a cable subscription!), something other similar boxes already do. How very unexciting. It’s surprising that Apple TV doesn’t already offer HBO Go, since its biggest competitors Roku and Xbox 360 have had it for over a year. And it’s not like Apple has spent that time coming up with some innovative arrangement that would that would excite the cord-cutter (and cord-never) set. No, per Bloomberg’s   Edmund Lee and Adam Satariano, by mid-2013, Apple TV owners who also subscribe to cable or satellite TV can watch the premium channel through their TVs via Apple’s box. Yes, if you have an Apple TV, you can watch HBO either on it or through your cable box. The choice is yours!

RELATED: Apple Won’t Be Revolutionizing TV Anytime Soon if Cable Has Their Say

HBO Go is a modest improvement over the HBO On Demand offerings because it offers HBO’s entire library of shows, not just a select few. HBO also puts brand new episodes up right after they air, which is nice for people who forget to set or have a too-full DVR. But, cable subscribers already have access to HBO Go—on their computers. The improvement here is that existing subscribers now have another way to get those shows onto their TV screens.

RELATED: HBO Is Finally OK with Cord Cutting (In Scandinavia)

This too-late move to get Time Warner on its box surfaces a larger problem: Apple TV has very few apps so far, as AllThingsD’s Peter Kafka points out. HBO Go will bring its total outside app count up to 10, a ton fewer than Xbox and Roku. And yet, many have talked about Apple TV as the gadget that will change everything. Perhaps techies overlooked the deficit because the company has been in secret talks with cable companies to supposedly revolutionize TV for years. It’s coming, the Apple rumors promised, fending off any doubts that Apple would deliver something great. But, nothing exceptional has arrived yet, certainly nothing that sounds like the Apple TV code Steve Jobs claimed to have cracked shortly before his death. Rather, this sounds like something Apple should have done years ago. Apple, if anything, is playing catch-up. 

RELATED: Apple Might Be Making Apple TV Content Deals

But maybe Apple isn’t the place to look for the future of television. Elsewhere in TV land, something new, different, and possibly revolutionary is happening. Netflix, an entity that does not require a cable subscription, will release its first big-budget TV drama today. Unlike Apple, Netflix is trying to operate outside of the traditional cable-bundle structure in order to create an alternative for people who don’t want to pay into the old system. Instead of playing by HBO’s rules and selling its shows on its strict terms, Netflix wants to be the HBO of streaming TV, by creating premium shows that will draw people to Netflix for a premium price. Also in an attempt to do things differently, Netflix has released all the episodes at once, to appeal to our binge watching sensibilities. The experiment might not work. But at least, unlike Apple, Netflix is trying. 

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Why is Beckham sitting on the bench for nothing?

PARIS (AP) — David Beckham has won league championships in three countries on two continents, earns millions of dollars in endorsements and his name is practically synonymous with celebrity itself. He has his own cologne, for goodness sake. So why is he even bothering to sit on the bench for the Paris Saint-Germain football club?

His royal highness of football doesn't need the money — and he's said he'll donate his PSG salary to charity — but he does need to start thinking about life after the game. At 37, Beckham is practically a dinosaur for the sport, and he acknowledged in his welcoming press conference on Thursday that he probably won't be in the team's starting lineup.

Instead, Beckham may be beginning to put in place a plan for life after the final whistle. Ellis Cashmore, a sociologist who writes about sports and media culture at Staffordshire University, said that prolonged exposure is always useful to celebrities building empires. In that way, the deal with PSG does double work: It keeps his name in lights for longer and also garners extra attention for the charitable contribution.

"When he does stop playing, which is going to be quite soon, his overall brand appeal will inevitably decline because we will inevitably forget about this guy," he said. "I think he's probably thinking, I want to stay in the shop window for a bit longer."

But Cashmore also cautioned against being too cynical in assessing Beckham's motives: "The guy is an athlete. He wants to do what he loves to do."

Bruno Satin, an independent players' agent who was with IMG for a decade, also said that the move to PSG — even if it's to sit on the bench — is a step up for Beckham.

"For him, to be on the PSG team, it's a higher level than being on the Los Angeles Galaxy," he said. "For the world of football, for real football, the Los Angeles Galaxy is nothing on the map of football."

Some wondered if Beckham was trying to avoid the notoriously sticky fingers of the French state with his plans to donate his salary.

But Sandra Hodzic, a tax lawyer with Salans, said the deduction an individual can take on such contributions is limited. Instead, it would be smarter for PSG to directly donate the salary — and take a big tax break in the process.

Doing so would have an added benefit for the club: UEFA, the governing body for European football, mandates that clubs break even. The donation could allow PSG to essentially write off Beckham's entire salary — a huge help for a team notorious for mega-contracts.

Beckham, meanwhile, would be better off trying to avoid becoming a French tax resident at all. So far, Hodzic said, he is making all the right moves: His family is staying in London, he plans to live only part-time in the country for less than six months, and his primary source of income —whether or not he donates his salary — isn't being earned in France.

Beckham's agent did not return calls for comment on specifics of the contract.

Still, the charitable contribution has raised the question about what Beckham is getting out of the deal. For one, he likely is still getting a cut of rights to his image. Jerseys with his name on them were already selling out at the PSG store on the Champs-Elysees on Friday.

Cashmore, who wrote a book called "Beckham," calls him a "marketing phenomenon" and estimates that about 70 percent of Beckham's income comes from endorsement deals — with Adidas, for instance. That makes salary almost irrelevant — especially for a man estimated by the Sunday Times Rich List to be worth 160 million pounds ($253 million).

But the football feeds the endorsements, Cashmore says.

"It makes an awful lot of business sense to perpetuate, to prolong his active competitive football career," he said, especially with a team that's doing fairly well this year. "It makes an awful lot of sense for him to showcase himself because it will generate more income from his various other sponsorship and licensing activities."

But certainly this move, as any at this late-stage in his playing career, is being made with an eye on what will come next. Cashmore said that when Beckham signed with the L.A. Galaxy, there was an understanding that he would eventually become an ambassador for American soccer. That plan clearly fell by the wayside — perhaps because Major League Soccer decided it was just too expensive to keep on the star after his presence on American soil failed to generate more interest in the game.

It's possible, Cashmore said, that Beckham is looking for a similar deal after his stint at PSG, which is Qatari-owned. The tiny, wealthy nation is hosting the World Cup in 2022, and Beckham's contract with PSG will establish a relationship with it; from there, a role as, say, an ambassador for the tournament would seem more natural.

"For his after-career conversion, it's important to have links with major actors in the world of sports," said Satin. And Qatar is certainly one. It has poured money into PSG, drawing major names like striker Zlatan Ibrahimovic. It also funds the satellite network Al Jazeera, which could provide Beckham with a platform. And then there's the World Cup.

In the end, though, Satin said the clue to Beckham's thinking may be as simple as the eternal draw of Paris.

"PSG has become a glamorous club, a pretty nice club in a beautiful city," said Bruno Satin, an agent. "It's just two hours on the Eurostar (train) from London."

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AP Sports Writer Rob Harris contributed to this report from London.

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Ferrol Sams, Doctor Turned Novelist, Dies at 90

Ferrol Sams, a country doctor who started writing fiction in his late 50s and went on to win critical praise and a devoted readership for his humorous and perceptive novels and stories that drew on his medical practice and his rural Southern roots, died on Tuesday at his home in Lafayette, Ga. He was 90.

The cause, said his son Ferrol Sams III, also a doctor, was that he was “slap wore out.”

“He lived a full life,” his son said. “He didn’t leave anything in the tank.”

Dr. Sams grew up on a farm in the rural Piedmont area of Georgia, seven mud-road miles from the nearest town. He was a boy during the Depression; books meant escape and discovery. He read “Robinson Crusoe,” then Mark Twain and Charles Dickens. One of his English professors at Mercer University, in Macon, suggested he consider a career in writing, but he chose another route to examining the human condition: medical school.

When he was 58 — after he had served in World War II, started a medical practice with his wife, raised his four children and stopped devoting so much of his mornings to preparing lessons for Sunday school at the Methodist church — he began writing “Run With the Horsemen,” a novel based on his youth. It was published in 1982.

“In the beginning was the land,” the book begins. “Shortly thereafter was the father.”

In The New York Times Book Review, the novelist Robert Miner wrote, “Mr. Sams’s approach to his hero’s experiences is nicely signaled in these two opening sentences.”

He added: “I couldn’t help associating the gentility, good-humored common sense and pace of this novel with my image of a country doctor spinning yarns. The writing is elegant, reflective and amused. Mr. Sams is a storyteller sure of his audience, in no particular hurry, and gifted with perfect timing.”

Dr. Sams modeled the lead character in “Run With the Horsemen,” Porter Osborne Jr., on himself, and featured him in two more novels, “The Whisper of the River” and “When All the World Was Young,” which followed him into World War II.

Dr. Sams also wrote thinly disguised stories about his life as a physician. In “Epiphany,” he captures the friendship that develops between a literary-minded doctor frustrated by bureaucracy and a patient angry over past racism and injustice.

Ferrol Sams Jr. was born Sept. 26, 1922, in Woolsey, Ga. He received a bachelor’s degree from Mercer in 1942 and his medical degree from Emory University in 1949. In his addition to his namesake, survivors include his wife, Dr. Helen Fletcher Sams; his sons Jim and Fletcher; a daughter, Ellen Nichol; eight grandchildren; and nine great-grandchildren.

Some critics tired of what they called the “folksiness” in Dr. Sams’s books. But he did not write for the critics, he said. In an interview with the Georgia Writers Hall of Fame, Dr. Sams was asked what audience he wrote for. Himself, he said.

“If you lose your sense of awe, or if you lose your sense of the ridiculous, you’ve fallen into a terrible pit,” he added. “The only thing that’s worse is never to have had either.”

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Letters: Seeing Lincoln as a C.E.O.

To the Editor:

Re “Lincoln’s School of Management” (Jan. 27), which described the decision-making strategy for the Emancipation Proclamation as a model for today’s executives: 

The article’s description of how “Americans reacted strongly to the proclamation” said nothing of how enslaved African-Americans reacted. Instead, it focused only on big political players, who might be considered the other C.E.O.’s in the game: abolitionists, Republican leaders, Union Democrats, Jefferson Davis, and The New York World.

Nor does it mention the major oversight of Lincoln’s management team: its failure to make supportive provisions for the many slaves who predictably embraced the emancipation promise and fled their masters, only to face equally predictable starvation and disease. Perhaps this case study should be rewritten to encourage business leaders to think a little bit less about how much they’re like Lincoln, and a little bit more about how their business decisions affect ordinary people in the real world.

MARK PETERSON

Berkeley, Calif., Jan. 27

The writer is a history professor at the University of California, Berkeley.

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The Caucus: Brown Decides Against Massachusetts Senate Bid

Scott P. Brown said on Friday that he had opted out of the Senate race in Massachusetts to fill the seat being vacated by John Kerry.

The decision leaves the Republicans without a candidate yet for the special election set for June 25, and it could leave the seat in Democratic hands.

Other potential Republican candidates had been waiting for a signal from Mr. Brown, who was seen as the strongest Republican, despite the loss of his Senate seat last year to Elizabeth Warren.

Mr. Brown spurned entreaties from the National Republican Senatorial Committee to use his statewide name recognition and popularity — and his leftover campaign treasury — to help the party gain a seat.

“I have received a lot of encouragement from friends and supporters to become a candidate, and my competitive instincts were leading in the same direction,” he said in a statement.

“Even so, I was not at all certain that a third Senate campaign in less than four years, and the prospect of returning to a Congress even more partisan than the one I left, was really the best way for me to continue in public service at this time,” he said. “And I know it’s not the only way for me to advance the ideals and causes that matter most to me.”

Mr. Brown first alerted The Boston Herald, which was strongly supportive of him during his last campaign, that he was not running.

“U are the first to know,” Mr. Brown said in a text message to The Herald.

Mr. Brown has told friends that he is exhausted from the lengthy and hard-fought campaign against Ms. Warren. He may run instead for governor in 2014, but for now his departure leaves the Republicans without a boldface name to try to wrest the seat from the Democrats.

There has been speculation that William F. Weld, the former governor who recently moved back to Massachusetts from New York, might mount a challenge. But one person close to him said that Mr. Weld viewed himself as an executive personality, not a legislative personality, and he has done nothing to indicate an interest in the Senate.

Other Republicans starting to surface include Gabriel Gomez, a businessman and a former member of the Navy SEALs, and State Representative Daniel Winslow, a former district court judge who served in the administration of Mitt Romney.

Whoever does decide to run has just four weeks to gather 10,000 signatures to get on the ballot.

Meanwhile, two Democratic congressmen, Edward J. Markey and Stephen Lynch, are already battling it out for their party’s nomination and will face off in a primary on April 30.

Mr. Lynch put out a statement on Friday saying: “I understand Scott Brown’s decision. He has basically been campaigning nonstop for three years. It’s perfectly understandable that he wouldn’t want to undertake another campaign.”

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Google moves closer to resolving EU investigation

BRUSSELS (Reuters) – Google has offered to take specific steps to allay competition regulators’ concerns about its business practices, in a major move towards ending a two-year investigation and avoiding billions of dollars in fines.

The European Commission said on Friday it had received detailed proposals from the world’s most popular search engine, which has been under investigation following complaints from more than a dozen companies, including Microsoft, that Google has used its market power to block rivals.

If the commission accepts the proposals under its settlement procedure, it would mean no fine and no finding of wrongdoing against Google.

Companies found to be in breach of EU rules can be fined as much as 10 percent of global turnover, which could mean up to $ 4 billion if there is no satisfactory resolution in Google’s case.

EU Competition Commissioner Joaquin Almunia told Reuters he had received Google’s submission, but declined to give details of the proposal.

“We are analyzing it,” he said.

Google spokesman Al Verney said the group continues to work cooperatively with the commission.

The company ranks first in Internet searching in Europe, with an 82 percent market share, versus 67 percent in the United States, according to research firm comScore.

Lobbying group ICOMP, whose members include complainants Microsoft, Foundem, Hot-map, Streetmap and Nextag, said any solution should include measures ensuring that rivals could compete on a level playing field with Google.

The FairSearch coalition, whose members include online travel agencies and complainants Expedia and TripAdvisor, said a third-party monitor should be appointed to ensure that Google lives up to any promises.

The commission, which acts as competition regulator in the 27-member European Union, is now expected to seek feedback from Google’s rivals and other interested parties, before launching an official market test.

Last month, Google won a major victory when U.S. antitrust regulators ended their investigation, saying the company had not manipulated its web search results to block rivals.

The commission has said Google may have favored its own search services over those of rivals, and copied travel and restaurant reviews from competing sites without permission.

The EU executive is also concerned the company may have put restrictions on advertisers and advertising to prevent them from moving their online campaigns to competing search engines.

(Reporting by Foo Yun Chee; Editing by Rex Merrifield and Hans-Juergen Peters)

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Macklemore & Ryan Lewis score unlikely hit

NASHVILLE, Tenn. (AP) — The rapper Macklemore thinks there's a simple reason the hit "Thrift Shop" appears to be going viral: It dares to be different.

"There's a certain sound that has kind of flooded the mainstream airwaves as far as hip-hop music," he said a few hours after taping a performance on "Late Show with David Letterman" on Thursday night with producing partner Ryan Lewis. "The beat doesn't sound anything like that, the lyrics are kind of completely polar opposite from what you hear from most commercial rap records and it's got a hook that's very catchy. So I think that you combine those three things and it equates to an original sounding song that's refreshing to the audience that hears it."

Listeners have responded with rare enthusiasm to the song about "poppin' tags" to develop your own unique sense of swag. "Thrift Shop" sits atop the Billboard Hot 100 radio airplay chart, the Nielsen SoundScan Digital Songs chart and is the No. 1 song on Spotify for two consecutive weeks. Only one other song, Bruno Mars' "Locked Out of Heaven," has reached the top of those lists simultaneously.

The Seattle-based duo has sold 2.3 million copies so far — a million in the last month alone — and sales continue to grow week to week. Macklemore, whose real name is Ben Haggerty, said he and Lewis thought the song might appeal to a "niche demographic" and didn't envision it becoming a single. The song's sense of humor is key, but Haggerty says there's also a deeper message about individuality and modern culture's obsession with expensive fashion.

"The more expensive the better is kind of the American way and if you spent $600 for a sweatshirt, then that makes it better," Haggerty said. "And I don't necessarily think that's the case. If it's a $600 sweatshirt that's fresh, that's fantastic if it looks great. But to me to just pay a ridiculous amount of money for something just because of the logo isn't creative and it's just unfortunate that people equate spending money to style."

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SciTimes Update: Recent Developments in Science and Health News

Michael Probst/Associated Press

Baby hedgehogs in Germany.

Friday in science, clues to owls’ backwardness, fresh dangers to the seas and the launch of a giant kite. Check out these and other headlines from around the Web.

Phil Marino for The New York Times

Physicists monitored data from heavy ion collisions in the control room at Brookhaven National Laboratory particle collider in 2007.

Felix Ordonez/Reuters

A snowy owl.

Hedgehog Bacteria: Sonic the Hedgehog may have a dark side. The Associated Press reports that in the last year, 20 people in the United States were infected, and 1 person died, from “a rare but dangerous” type of salmonella bacteria. All the cases, health officials said, were linked to hedgehogs that were kept as pets.

More Bad News for the Seas: National Geographic reports that buried beneath the waves are rich deposits of “gold, copper, zinc, and other valuable minerals,” and that is attracting the attention of the humans on the land above. Mining the minerals is not easy, but one company has already obtained an extraction contract for the waters off Papua, New Guinea, the magazine says.

Less Money for Science: Lean days are ahead for recipients of federal government contracts, and that knowledge is having an impact on physics research. Scientific American reports that a federal advisory panel has recommended closing a particle collider at Brookhaven National Laboratory in Upton, N.Y.

Spinning Heads: Owls are able to do something that parents only dream about: swivel their heads completely around to see what is going on behind them. An illustrator and a physician at the Johns Hopkins University School of Medicine discovered that they can do so without severing their arteries or preventing blood from reaching their brains because of holes in their neck bones, which may hold air sacks that cushion the movement of the head, and because the vertebral artery is able to expand and hold reservoirs of blood for the brain, a LiveScience video explains.

Setting Sail in Space: A new solar sail, the largest yet, will be launched by NASA in 2014. Looking very much like a gigantic kite, it will eventually reach 2 million miles from Earth (that’s a lot of string!), Popular Science reports. And besides blazing the way for further research of this type, the mission has another purpose: “Sunjammer will be carrying the cremated remains of various individuals, including the creator of Star Trek,Gene Roddenberry, and his wife Majel Barrett Roddenberry. It is not exactly the Enterprise, but Sunjammer will be boldly going where no solar sailing spacecraft has gone before,” Popular Science says.

Video by NASAMarshallTV

Solar Sail Readies for Early Warning Mission

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Off the Charts: For Markets, a Strong January Is a Good Sign

AS January goes, so goes the year.

That maxim of the American stock market would seem to bode well for the market this year. The Standard & Poor’s 500-stock index’s gain of 5 percent made the month the 12th best January since 1950, and the 19th opening month in that period when the index rose more than 4 percent.

“If history repeats, we would expect a double-digit percentage increase in the upcoming 11 months,” said Richard Peterson, an analyst at S&P Capital IQ.

Only once since 1950 has the market fallen in the last 11 months of a year when it rose 4 percent or more in January. That was in 1987, which began with the best January in the history of the index — up 13.2 percent — and ended including the worst single day ever for the index, a 20 percent plunge on Oct. 19.

On average since 1950, January gains of at least 4 percent have been followed by rises of 15.1 percent in the remainder of the year. Gains were lower when January gains were smaller, and on average the market has made no headway in years after prices fell in January.

There is, of course, no guarantee that history will repeat. In fact, during the Great Depression the opposite pattern existed. The market rose sharply during the first month of 1929, 1930, 1931 and 1934, only to plunge the rest of each year. Prices fell in the first month of 1935, which turned out to be an excellent year.

The January gains this year reflected generally strong markets around the world. As can be seen in the accompanying charts, all but two of the 20 largest stock markets in the world rose in January, and six of them — Japan, China, Britain, Switzerland, Sweden and Italy — rose more rapidly than the American market did. The two that showed losses were Brazil and South Korea.

The ranking of markets is based on World Bank calculations of total market capitalization of each market in 2011. More than half the capitalization of those 20 markets is in just the top three, the United States, Japan and China. The top five — Britain and Canada in addition to the other three — have two-thirds of the value.

The United States market is one of 10 that have more than doubled from their credit crisis lows set in 2008 or 2009, the others being Brazil, Germany, India, South Korea, Hong Kong, South Africa, Russia, Sweden and Mexico.

The only three countries in the group that are not at least 50 percent higher than their lows are all in the euro zone, where economies have been stumbling. They are France, Spain and Italy.

Floyd Norris comments on finance and the economy at nytimes.com/economix.

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Snowmobile Rider Dies From X Games Injuries

Eric Lars Bakke/ESPN Images, via Associated Press

Caleb Moore in a photograph taken last January.

Caleb Moore, a 25-year-old snowmobiler injured last week during the Winter X Games in Aspen, Colo., died Thursday.

Christian Murdock/The Gazette, via Associated Press

Moore crashing during the snowmobile freestyle finals during the first day of the Winter X Games last Thursday.

Moore, from Krum, Tex., sustained a concussion and a heart contusion last Thursday after he landed short while attempting a backflip during the freestyle event, where competitors have 75 seconds to complete as high-flying aerial stunts on their snowmobiles. The skis on the front of his snowmobile pierced the top of the snow-covered landing ramp, and Moore fell face first into the snow. His bouncing snowmobile, weighing nearly 500 pounds, landed on top of him, knocking him unconscious.

Moore regained consciousness after a couple of minutes, surrounded by paramedics, his father, and his brother, Colten, also a competitor and the X Games gold medalist in the event in 2012. He stood and gingerly walked away, but was taken to a local hospital with a preliminary diagnosis of a concussion.

Early Friday, doctors found bleeding near his heart, and Moore was airlifted to a hospital in Grand Junction, Colo., where he underwent surgery and was listed in critical condition.

On Sunday, a family spokeswoman said that the “cardiac injury has led to a secondary complication involving his brain,” but no further details were provided. On Monday, Moore’s grandfather, Charles Moore, told The Denver Post, “It’s almost certain he’s not going to make it.”

The Moore family released a statement confirming the death, saying, “The family wishes to express their deep gratitude for all the prayers and support they have received from all the fans, friends and family around the world that Caleb has inspired.”

Moore was an accomplished trick artist on four-wheel all-terrain vehicles who, along with his brother, learned how to do similar tricks on snowmobiles in the weeks before the 2010 Winter X Games. Caleb, despite only weeks of practice on the snow, won a bronze medal that year.

ESPN, the organizer of the X Games, also released a statement.

“We are deeply saddened by Caleb Moore’s passing and our thoughts and prayers go out to his parents, Wade and Michelle, his brother, Colten, and the entire Moore family. He will be remembered for his natural passion for life and his deep love for his family and friends, and he will always be an inspiration to everyone he touched in the action sports community.

“As a result of this accident we will conduct a thorough review of this discipline and adopt any appropriate changes to future X Games.For 18 years we have worked closely on safety issues with athletes, course designers and other experts. Still, when the world’s best compete at the highest level in any sport, risks remain. Caleb was a four-time X Games medalist attempting a move he has landed several times previously.”

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The 7 most dedicated employees

You probably don’t want to forward this roster of tireless go-getters to your boss

Some people probably feel they deserve a medal for merely getting up and going to work every day, but only a few actually merit one. Take Deborah Ford, for example. This 64-year-old Detroit postal worker, who recently retired, didn’t use a single sick day in all of her 44 years on the job. Not a single one! For doctor’s appointments, she would take vacation days, and when she was feeling lousy she says she would just “shake it off.” At the end of her dedicated career, Ford had amassed a sick-leave balance of 4,508 hours. But before you give her the award for most dedicated employee, check out this lot:

1. Going the distance
Unless you work from home, chances are you endure a less-than-pleasant commute. But none is likely as arduous as that of Dave Givens. In 2006 the Mariposa, Calif., resident earned the unenviable award for “America’s Longest Commute” when tire company Midas set out to find the employee who trekked the most miles to work. From his ranch home in Mariposa, Givens drives 186 miles to his job at Cisco Systems, Inc., in San Jose. The electrical engineer has been making this 372-mile round trip, which equals a total of seven hours of driving, for 17 years. “I have a great job and my family loves the ranch where we live,” Givens said. “So this is the only solution.” His dedication to the horrendous commute earned Givens the grand prize of $ 10,000 and some much-needed gas money as well as an array of Midas maintenance services and products.

SEE ALSO: Today in business: 5 things you need to know

2. A life’s work
Rose Syracuse Richardone “just loves to work,” says Macy’s senior vice president Robin Hall of the 92-year-old employee. Richardone retired from Macy’s in September 2012 after working in a range of positions from her first job at the age of 17 in the accounts department — back when there weren’t credit cards and customers would set aside money in the in-store bank to pay for items — to her final position within the parade and entertainment group. To honor her 70th year with the company a few years ago, Macy’s management arranged for Richardone to cut the red ribbon that launched the iconic Thanksgiving parade. Had it not been for a broken hip, the diminutive employee might still be working today. “Life is good,” she said of her longevity. “You go on each day, you’re happy where you’re at. And people — bosses, supervisors, they appreciate you. And you stay.”

3. Hardest working unemployed man
You may not know Justin Knapp, but you’re likely familiar with his work. Knapp is a voluntary editor of the Wikipedia, and last April the 30-year-old became the first person to complete 1 million edits on the massive online, open-source encyclopedia. After coming across Wikipedia in 2003, Knapp registered as an editor in 2005 and now spends several hours per day combing, editing, and adding to Wikipedia articles. His edits can be as small as ensuring em dashes and en dashes are used properly or as substantial as building the most comprehensive George Orwell entry, which reportedly took about 100 hours. But Knapp relishes the work. “Editing these projects is relaxing and rewarding,” Knapp told Gizmodo. Knapp doesn’t get paid for his work, however plentiful, but he manages to get by financially with odd jobs while he pursues his nursing degree at Indiana University. Ultimately he feels his diligence is for the greater good. “Far be it for me to say that it’s an act of love to edit Wikipedia,” he said. “But I really do feel like that it helps other human beings. That makes me feel good — knowing that somehow I can be a small part of helping someone who I’ll never know.”

SEE ALSO: Today in business: 5 things you need to know

4. Dedicated volunteer
Don Moss is the “Energizer Bunny of volunteers.” As of 2010, the Wake Forest University Baptist Medical Center volunteer has clocked in more than 47,000 hours, setting a Guinness World Record for his time. For the last 28 years, Moss has worked at Wake Forest Monday through Thursday, 48 hours per week. The 63-year-old’s dedication is a personal one. In 1980, Moss was in a freak accident that landed him at Wake Forest Baptist where he spent three months in a coma with a major head injury. Doctors didn’t think he would make it and, after he woke up, specialists said he would never walk again. But Moss defied all expectations and now, after being encouraged to volunteer during his rehabilitation stint, he’s rarely idle. While working, Moss delivers letters to patients, helps out at the gift shop, and guides lost visitors to their destinations. And those free Fridays? Those are for his wife, he says: “That’s my honey-do list day.”

5. Hardest working mom
Dr. Helen Wright felt like she had it all — she loved her job as a headmistress at an exclusive British all-girls school, and she had time to enjoy her beautiful growing family. On February morning in 2010, when Wright was pregnant with her third child, she went into labor. Within an hour she had given birth to the baby, a girl named Jessica, and by lunchtime, Wright was back at work, her newborn in tow. This was nothing new for her. She had never taken maternity leave with any of her children. Her second child was born on a Friday; Wright was back at work by Monday. Given the ongoing can-women-have-it-all debate, Wright says she wants to be a role model for her students to show them that they too can have a career and a family, quite literally, in the same space. The rarely trodden path of bringing your baby to work is, Wright says, the option more women should consider. “Most women have a choice of taking maternity leave or going back to work and having their babies looked after. Why can’t there be a third way?”

SEE ALSO: Today in business: 5 things you need to know

6. Hardest working country
Do you feel like you work long hours? Well, here’s some food for thought: Employees in Asian countries have the highest proportion of employees who work more than 48 hours per week, which is considered “excessive.” Of those Asian countries, South Korea is the most overworked: According to data compiled by the Organization for Economic Cooperation and Development, South Koreans work a whopping 2,193 hours per year. Chile comes in second with 2,068 hours, which far exceeds the average for most developing countries, which is 1,718 hours annually. The United States is just below the average with 1,695 hours. Germany and the Netherlands remain on the low end of the scale with 1,408 hours and 1,377 hours per year, respectively. Tighter labor laws in developed countries, particularly Europe, have contributed to reduced working hours, so, you know, don’t feel too bad about it, you’re just playing by the rules.

7. Hardest working American town
Columbia, Mo., managed to keep its unemployment rate of 6.0 percent throughout the worst economic downturn since the Depression with the help of its robust health-care and education sectors. The town has six hospitals and the second highest number of hospital beds per capita in the country. It’s also home to the University of Missouri-Columbia, which employs some 8,000 people, as well as six other institutions of higher education. More than 80 percent of households are dual-income, and the city ranked second on likelihood to work on the weekends, according to data compiled by Parade magazine in 2012. 

SEE ALSO: Today in business: 5 things you need to know

Sources: BBC, Daily Mail, Gizmodo, Parade, The Stir, Yahoo

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Beyonce to finally face media in New Orleans

NEW ORLEANS (AP) — Beyonce is expected to face the media Thursday as she previews her halftime performance at the Super Bowl. But the focus will likely be on her performance at that other big event earlier this month.

The superstar hasn't spoken publicly since it was alleged that she lip-synched her rendition of "The Star-Spangled Banner" at President Barack Obama's inauguration last week. Her critically praised performance came under scrutiny less than a day later when a representative from the U.S. Marine Band said she wasn't singing live and the band's accompanying performance was taped. Shortly after, the group backed off its initial statement and said no one could tell if she was singing live or not.

It's expected that the halftime performance will be a main focus of her afternoon press conference, even though she'd likely rather concentrate on questions about her set list for Sunday and her upcoming HBO documentary, "Life Is but a Dream." The documentary is being shown for the media just before Beyonce speaks and takes questions, as expected.

There has been plenty of speculation about Beyonce's Super Bowl performance, including reports there would be a Destiny's Child reunion with Michelle Williams and Kelly Rowland (Williams has shot down such speculation). Some are also curious about whether her husband, Jay-Z, will join her onstage, as they often do for each other's shows.

Beyonce has teased photos and video of herself preparing for the show, which will perhaps be the biggest audience of her career. Last year, Madonna's halftime performance was the most-watched Super Bowl halftime performance ever, with an average of 114 million viewers. It garnered more viewers than the game itself, which was the most-watched U.S. TV event in history.

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During Trial, New Details Emerge on DuPuy Hip

When Johnson & Johnson announced the appointment in 2011 of an executive to head the troubled orthopedics division whose badly flawed artificial hip had been recalled, the company billed the move as a fresh start.

But that same executive, it turns out, had supervised the implant’s introduction in the United States and had been told by a top company consultant three years before the device was recalled that it was faulty.

In addition, the executive also held a senior marketing position at a time when Johnson & Johnson decided not to tell officials outside the United States that American regulators had refused to allow sale of a version of the artificial hip in this country.

The details about the involvement of the executive, Andrew Ekdahl, with the all-metal hip implant emerged Wednesday in Los Angeles Superior Court during the trial of a patient lawsuit against the DePuy Orthopaedics division of Johnson & Johnson. More than 10,000 lawsuits have been filed against DePuy in connection with the device — the Articular Surface Replacement, or A.S.R. — and the Los Angeles case is the first to go to trial.

The information about the depth of Mr. Ekdahl’s involvement with the implant may raise questions about DePuy’s ability to put the A.S.R. episode behind it.

Asked in an e-mail why the company had promoted Mr. Ekdahl, a DePuy spokeswoman, Lorie Gawreluk, said the company “seeks the most accomplished and competent people for the job.”

On Wednesday, portions of Mr. Ekdahl’s videotaped testimony were shown to jurors in the Los Angeles case. Other top DePuy marketing executives who played roles in the A.S.R. development are expected to testify in coming days. Mr. Ekdahl, when pressed in the taped questioning on whether DePuy had recalled the A.S.R. because it was unsafe, repeatedly responded that the company had recalled it “because it did not meet the clinical standards we wanted in the marketplace.”

Before the device’s recall in mid-2010, Mr. Ekdahl and those executives all publicly asserted that the device was performing extremely well. But internal documents that have become public as a result of litigation conflict with such statements.

In late 2008, for example, a surgeon who served as one of DePuy’s top consultants told Mr. Ekdahl and two other DePuy marketing officials that he was concerned about the cup component of the A.S.R. and believed it should be “redesigned.” At the time, DePuy was aggressively promoting the device in the United States as a breakthrough and it was being implanted into thousands of patients.

“My thoughts would be that DePuy should at least de-emphasize the A.S.R. cup while the clinical results are studied,” that consultant, Dr. William Griffin, wrote.

A spokesman for Dr. Griffin said he was not available for comment.

The A.S.R., whose cup and ball components were both made of metal, was first sold by DePuy in 2003 outside the United States for use in an alternative hip replacement procedure called resurfacing. Two years later, DePuy started selling another version of the A.S.R. for use here in standard hip replacement that used the same cup component as the resurfacing device. Only the standard A.S.R. was sold in the United States; both versions were sold outside the country.

Before the device recall in mid-2010, about 93,000 patients worldwide received an A.S.R., about a third of them in this country. Internal DePuy projections estimate that it will fail in 40 percent of those patients within five years; a rate eight times higher than for many other hip devices.

Mr. Ekdahl testified via tape Wednesday that he had been placed in charge of the 2005 introduction of the standard version of the A.S.R. in this country. Within three years, he and other DePuy executives were receiving reports that the device was failing prematurely at higher than expected rates, apparently because of problems related to the cup’s design, documents disclosed during the trial indicate.

Along with other DePuy executives, he also participated in a meeting that resulted in a proposal to redesign the A.S.R. cup. But that plan was dropped, apparently because sales of the implant had not justified the expense, DePuy documents indicate.

In the face of growing complaints from surgeons about the A.S.R., DePuy officials maintained that the problems were related to how surgeons were implanting the cup, not from any design flaw. But in early 2009, a DePuy executive wrote to Mr. Ekdahl and other marketing officials that the early failures of the A.S.R. resurfacing device and the A.S.R. traditional implant, known as the XL, were most likely design-related.

“The issue seen with A.S.R. and XL today, over five years post-launch, are most likely linked to the inherent design of the product and that is something we should recognize,” that executive, Raphael Pascaud wrote in March 2009.

Last year, The New York Times reported that DePuy executives decided in 2009 to phase out the A.S.R. and sell existing inventories weeks after the Food and Drug Administration asked the company for more safety data about the implant.

The F.D.A. also told the company at that time that it was rejecting its efforts to sell the resurfacing version of the device in the United States because of concerns about “high concentration of metal ions” in the blood of patients who received it.

DePuy never disclosed the F.D.A. ruling to regulators in other countries where it was still marketing the resurfacing version of the implant.

During a part of that period, Mr. Ekdahl was overseeing sales in Europe and other regions for DePuy. When The Times article appeared last year, he issued a statement, saying that any implication that the F.D.A. had determined there were safety issues with the A.S.R. was “simply untrue.” “This was purely a business decision,” Mr. Ekdahl stated at that time.

This article has been revised to reflect the following correction:

Correction: January 30, 2013

A capsule summary of an earlier version of this article described the start of the DePuy trial incorrectly. It began last week, not this week.

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Media Decoder Blog: Ratings Shortfall at Nickelodeon Hurts Viacom Revenue

1:34 p.m. | Updated Hampered by ratings shortfalls at Nickelodeon and an unfavorable film release schedule, Viacom on Thursday reported a 16 percent decrease in revenue in the fourth quarter of 2012, a somewhat steeper drop than analysts anticipated.

But the company’s profits came in slightly ahead of expectations, and the chief executive, Philippe Dauman, pleased Wall Street with positive news about progress at Nickelodeon and Viacom’s other cable networks.

Mr. Dauman said the company was making an “unprecedented investment in content” that was paying off for Nickelodeon. The dramatic ratings declines that began to be visible in late 2011 are moderating, and new shows are premiering. Mr. Dauman said the ratings momentum “confirms our view that our significant and sustained investment in fresh, original content is working, and will continue to drive future ratings growth and revenue improvement.”

Viacom reported revenue in the fourth quarter of 2012, its fiscal first quarter, of $3.3 billion, down from $3.95 billion in the same quarter a year ago. Analysts had forecast $3.48 billion in revenue.

Profits rose to $470 million, or 92 cents a share, compared with $212 million, or 38 cents a share, in the same quarter a year ago. But the year-ago quarter was hurt by a settlement with the original shareholders of Harmonix Music Systems, the makers of the “Rock Band” video game series. After adjustments, Viacom earned 91 cents a share in the quarter, a penny higher than analysts had predicted, from $1.06 in the same quarter a year ago.

The damage done by Nickelodeon’s ratings drop was evident in the total revenues for Viacom’s cable networks, by far the biggest part of its business. Revenue dipped 2 percent at the networks overall, largely because advertising revenue decreased 6 percent, even as affiliate fees paid by cable and satellite distributors grew.

Mr. Dauman said on a conference call with analysts that the “lingering effects of the ratings softness” at Nickelodeon masked growth elsewhere at the cable networks. Excluding its children’s channels, Viacom’s networks group “returned to positive ad growth in the quarter,” he said.

David Bank, a media analyst for RBC Capital Markets, said Nickelodeon’s ratings for the last few months were showing recovery after a rocky 2012. “All they need to do is continue to deliver the audience they are already delivering — without growth — and the year-over-year comparisons virtually assure growth,” he said.

Nickelodeon will pitch a slate of new animated and live-action series to advertisers at a presentation in late February. One of the areas of focus is preschool programming — the idea being that very young viewers will stick with Nickelodeon throughout their childhood.

Mr. Dauman says Viacom has found that its viewers of all ages want more new shows, and they want more episodes of those shows on “faster cycles,” so it has sped up the development and production processes at Nickelodeon and elsewhere.

Mr. Dauman spent some time on Thursday’s earnings call praising MTV, another one of its flagship networks, which he said had started to answer the question “What comes after ‘Jersey Shore?’” That infamous reality show had its series finale earlier this winter.

“‘Jersey Shore’ was a game-changing hit,” he said, “but it also precipitated an overemphasis on one night,” which was Thursday. MTV is trying to spread its new shows — “Catfish,” “Washington Heights,” “Buckwild” — across the weekly schedule.

Viacom’s film studio, Paramount, saw revenue drop 37 percent in the quarter, to $975 million. The company attributed this to the fact that its films in the quarter weren’t as successful as year-ago hits like “Mission: Impossible – Ghost Protocol” and “Puss in Boots.” The company also had one fewer release in the home video marketplace this time around.

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The Lede Blog: Updates From the Senate Hearing on Gun Violence

The Lede followed the testimony on Wednesday before the Senate Judiciary Committee’s hearing titled “What Should America Do About Gun Violence?” Former Representative Gabrielle Giffords of Arizona, her husband, Mark E. Kelly, and Wayne LaPierre, chief executive of the National Rifle Association, are among the witnesses expected to testify. As our colleague Jennifer Steinhauer reports, this is the first hearing since the Dec. 14 mass shooting at an elementary school in Newtown, Conn., that killed 20 schoolchildren and 6 staff members.

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California police probe stunts that shut down freeways

LOS ANGELES (Reuters) – The California Highway Patrol is investigating two apparently unrelated stunts that jammed freeways over the weekend, including one involving hundreds of motorcyclists celebrating a marriage proposal that inconvenienced motorists east of Los Angeles.

Both events created a flurry of viral Internet videos, fueling concerns about a repeat performance by copycats.

On Interstate 10 east of Los Angeles on Sunday, up to 300 bikers stopped traffic so that one of them could propose to his girlfriend, said Officer Vince Ramirez, a Los Angeles-area spokesman for the California Highway Patrol.

Video that surfaced online of the stunt showed some bikers creating a wall of smoke by spinning their tires against the concrete. In the middle of the gathering, pink smoke could be seen wafting into the air.

As they exited the freeway, several bikers were later ticketed for reckless riding unrelated to their possible role in the freeway shutdown, Ramirez said.

He said officers were working with the Los Angeles County District Attorney‘s office to prepare additional charges against some of the bikers.

The stunt did not cause any injuries or collisions, he said.

In Oakland on Saturday, traffic ground to a halt on Interstate 880 near the city’s sports coliseum, as several sports cars did doughnuts, spinning around and filling the air with tire smoke, officials said. Stunned motorists exited their cars and watched.

Several motorists caught in the sudden traffic jam were frightened or angry, according to recordings of calls to authorities released on Tuesday.

“I can’t believe this – I have three kids in the car,” one caller told an Oakland-area dispatcher. “It scares the hell out of me.”

Authorities have not found or identified any of the drivers, said California Highway Patrol Sergeant Diana McDermott.

California Highway Patrol officers said they feared the weekend events’ popularity on social media websites could start a dangerous trend. So far, such stunts have been rare, they said.

“That’s why the investigation is expanding,” Ramirez said.

“If there are any criminal charges that can be filed as a result of this incident, they will be filed,” he said.

(Editing by Alex Dobuzinskis, Tom Brown and Eric Walsh)

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'Entourage' crew to make leap to big-screen

LOS ANGELES (AP) — Vincent Chase and his entourage are jumping from the small screen to the big-screen.

Warner Bros. confirmed Wednesday that a film version of HBO's hit series "Entourage" is in the works.

Series creator Doug Ellin is writing and directing the film, which does not yet have a production start date or release date. The studio also has not finalized the cast.

"Entourage" ran for eight seasons and followed the Hollywood exploits of hot young actor Vince (Adrian Grenier) and his inner circle, including Kevin Connolly as his manager, Kevin Dillon as his half brother, Jerry Ferrara as an old neighborhood friend and Jeremy Piven as his slick super-agent.

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The Consumer: The Drug-Dose Gender Gap

Most sleeping pills are designed to knock you out for eight hours. When the Food and Drug Administration was evaluating a new short-acting pill for people to take when they wake up in the middle of the night, agency scientists wanted to know how much of the drug would still be in users’ systems come morning.

Blood tests uncovered a gender gap: Men metabolized the drug, Intermezzo, faster than women. Ultimately the F.D.A. approved a 3.5 milligram pill for men, and a 1.75 milligram pill for women.

The active ingredient in Intermezzo, zolpidem, is used in many other sleeping aids, including Ambien. But it wasn’t until earlier this month that the F.D.A. reduced doses of Ambien for women by half.

Sleeping pills are hardly the only medications that may have unexpected, even dangerous, effects in women. Studies have shown that women respond differently than men to many drugs, from aspirin to anesthesia. Researchers are only beginning to understand the scope of the issue, but many believe that as a result, women experience a disproportionate share of adverse, often more severe, side effects.

“This is not just about Ambien — that’s just the tip of the iceberg,” said Dr. Janine Clayton, director for the Office of Research on Women’s Health at the National Institutes of Health. “There are a lot of sex differences for a lot of drugs, some of which are well known and some that are not well recognized.”

Until 1993, women of childbearing age were routinely excluded from trials of new drugs. When the F.D.A. lifted the ban that year, agency researchers noted that because landmark studies on aspirin in heart disease and stroke had not included women, the scientific community was left “with doubts about whether aspirin was, in fact, effective in women for these indications.”

Because so many drugs were tested mostly or exclusively in men, scientists may know little of their effects on women until they reach the market. A Government Accountability Office study found that 8 of 10 drugs removed from the market from 1997 through 2000 posed greater health risks to women.

For example, Seldane, an antihistamine, and the gastrointestinal drug Propulsid both triggered a potentially fatal heart arrhythmia more often in women than in men. Many drugs still on the market cause this arrhythmia more often in women, including antibiotics, antipsychotics, anti-malarial drugs and cholesterol-lowering drugs, Dr. Clayton said. Women also tend to use more medications than men.

The sex differences cut both ways. Some drugs, like the high blood pressure drug Verapamil and the antibiotic erythromycin, appear to be more effective in women. On the other hand, women tend to wake up from anesthesia faster than men and are more likely to experience side effects from anesthetic drugs, according to the Society for Women’s Health Research.

Women also react differently to alcohol, tobacco and cocaine, studies have found.

It’s not just because women tend to be smaller than men. Women metabolize drugs differently because they have a higher percentage of body fat and experience hormonal fluctuations and the monthly menstrual cycle. “Some drugs are more water-based and like to hang out in the blood, and some like to hang out in the fat tissue,” said Wesley Lindsey, assistant professor of pharmacy practice at Auburn University, who is a co-author of a paper on sex-based differences in drug activity.

“If the drug is lipophilic” — attracted to fat cells — “it will move into those tissues and hang around for longer,” Dr. Lindsey added. “The body won’t clear it as quickly, and you’ll see effects longer.”

There are also sex differences in liver metabolism, kidney function and certain gastric enzymes. Oral contraceptives, menopause and post-menopausal hormone treatment further complicate the picture. Some studies suggest, for example, that when estrogen levels are low, women may need higher doses of drugs called angiotensin receptor blockers to lower blood pressure, because they have higher levels of proteins that cause the blood vessels to constrict, said Kathryn Sandberg, director of the Center for the Study of Sex Differences in Health, Aging and Disease at Georgetown.

Many researchers say data on these sex differences must be gathered at the very beginning of a drug’s development — even before trials on human subjects begin.

“The path to a new drug starts with the basic science — you study an animal model of the disease, and that’s where you discover a drug target,” Dr. Sandberg said. “But 90 percent of researchers are still studying male animal models of the disease.”

There have been improvements. In an interview, Dr. Robert Temple, with the Center for Drug Evaluation and Research at the F.D.A., said the agency’s new guidelines in 1993 called for studies of sex differences at the earliest stages of drug development, as well as for analysis of clinical trial data by sex.

He said early research on an irritable bowel syndrome drug, alosetron (Lotronex), suggested it would not be effective in men. As a result, only women were included in clinical trials, and it was approved only for women. (Its use is restricted now because of serious side effects.)

But some scientists say drug metabolism studies with only 10 or 15 subjects are too small to pick up sex differences. Even though more women participate in clinical trials than in the past, they are still underrepresented in trials for heart and kidney disease, according to one recent analysis, and even in cancer trials.

“The big problem is we’re not quite sure how much difference this makes,” Dr. Lindsey said. “We just don’t have a good handle on it.”

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Readers may submit comments or questions for The Consumer by e-mail to consumer@nytimes.com.

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DealBook: Top Federal Prosecutor of Corporate Crime Will Resign

1:42 p.m. | Updated with formal announcement

Lanny A. Breuer, the federal prosecutor who led the Justice Department’s response to corporate crime in the wake of the financial crisis, announced on Wednesday that he is stepping down after nearly four years in the post.

As head of the Justice Department’s criminal division, one of the most senior roles at the agency, Mr. Breuer tackled corporate bribery and public corruption. But it was his focus on Wall Street that received the most attention, from supporters and critics alike.

While he has come under fire for a dearth of prosecutions on Wall Street in response to the crisis, Mr. Breuer also oversaw an aggressive crackdown on money-laundering and interest-rate manipulation at some of the world’s biggest banks. In two weeks last month, he joined a nearly $2 billion case against HSBC for money-laundering and a $1.5 billion settlement with UBS for rate-rigging. Next week, he is expected to take a similar rate-rigging action against the Royal Bank of Scotland.

“I think the criminal division is a fundamentally different place than it was four years ago,” Mr. Breuer said in an interview on Tuesday. “It’s the highlight of my professional career.”

His departure, effective March 1, was widely expected. Mr. Breuer had told friends for weeks that he was ready to leave the public sector. While he has not announced his next step, it is expected that he will return to private practice. He was previously a partner at Covington & Burling, a white-shoe law firm.

By virtue of his perch at the Justice Department in Washington, Mr. Breuer became the face of Wall Street prosecutions in the aftermath of the financial crisis. But when few such cases materialized, critics like the Occupy Wall Street protesters turned on him, portraying him as an apologist for banks at the center of the mortgage mess.

In contrast, he drew praise for the sweeping crackdown on rate-rigging in the banking industry, which has largely involved international benchmark rates.

In a rate manipulation case last month, Mr. Breuer’s team secured a major payout from UBS and a guilty plea from the bank’s Japanese unit, making UBS the first big global bank in more than two decades to have a subsidiary plead guilty to fraud. Mr. Breuer, who announced the action after rejecting a last-minute plea from the bank’s chairman, also filed criminal charges against two former employees at the bank.

The deal sent a strong signal that the authorities wanted to hold banks responsible for their wrongdoing.

Following the UBS model, the Justice Department is now pursuing a guilty plea from a Royal Bank of Scotland subsidiary in Asia over its role in the interest rate manipulation scandal, people briefed on the matter said. That settlement, which could come as soon as next week, is likely to include more than $650 million in fines imposed by American and British authorities, two other people with direct knowledge of the matter said.

In an interview, Mr. Breuer said the rate-rigging case amounted to “egregious criminal conduct.” He struck a similar tone about two other major financial cases — the convictions of executives from Taylor, Bean & Whitaker, a now-defunct mortgage lender, and the 110-year prison term imposed on R. Allen Stanford for his Ponzi scheme.

Mr. Breuer has also focused on money-laundering, creating a task force in 2010 that has levied more than $3 billion in fines from banks, including the record fine against HSBC. He stopped short of indicting HSBC after some regulators warned that doing so could destabilize the global financial system.

Mr. Breuer argued that the charges he did not bring — for example, against Goldman Sachs and other banks suspected of fraud after selling toxic mortgage securities to investors — could not have been proved. It was not for a lack of trying, he said, noting that United States attorneys across the country, after reviewing the same evidence he did, also declined to act.

“It’s important for me to hold the financial institutions accountable,” he said. “There’s never been a time that a prosecutor said we should bring a securitization case and I said no.”

Under Mr. Breuer, the division has also increasingly used a 1977 law, the Foreign Corrupt Practices Act, to prosecute corporate bribery.

He also helped run the Justice Department’s investigation of the BP oil spill in the Gulf of Mexico, resulting in the company paying $4.5 billion in fines and other penalties and pleading guilty to 14 criminal charges related to the rig explosion in 2010.

In a statement, Attorney General Eric H. Holder Jr. praised Mr. Breuer. “Lanny has led one of the most successful and aggressive criminal divisions in the history of the Department of Justice,” he said.

Mr. Holder stood behind Mr. Breuer when questions arose about his involvement in the botched gun-trafficking case known as Operation Fast and Furious. The pair, who were both largely cleared after an inspector general investigation, worked together at Covington.

For years, Mr. Breuer moved in and out of government. The son of Holocaust survivors who fled Europe and settled in Queens, he landed at the Manhattan district attorney’s office after graduating from Columbia Law School. In between stints at Covington, he worked as a White House special counsel, defending President Bill Clinton amid federal investigations and impeachment proceedings.

In the interview on Tuesday, Mr. Breuer reflected on his unusual path to the Justice Department.

“The fact that I got to go from Elmhurst, Queens, to the criminal division is remarkable,” he said.

A version of this article appeared in print on 01/30/2013, on page B3 of the NewYork edition with the headline: Top Federal Prosecutor of Corporate Crime Will Resign.

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Report Links Rodriguez and Others to Clinic and P.E.D.’s

An anti-aging clinic in Coral Gables, Fla., that had been under the scrutiny of Major League Baseball for several months has now been cited in a published report as a supplier of performance-enhancing drugs to a half-dozen players, including the Yankees’ Alex Rodriguez.

Miami New Times, in a report released Tuesday, said that an unidentified former employee of the clinic, Biogenesis of America, which is now closed, had provided it with medical records from the facility that tie Rodriguez, Melky Cabrera, Gio Gonzalez, Bartolo Colon, Nelson Cruz and Yasmani Grandal to the use of performance-enhancers.

The newspaper accompanied the online article with copies of what it said were handwritten notations from the clinic that list various drugs allegedly distributed to its clients.

Cabrera, Colon and Grandal were suspended in the past year by baseball for positive drug tests. Gonzalez and Cruz have not previously been linked to the use of performance-enhancers. Rodriguez, who is now recovering from hip surgery, has admitted to using performance-enhancers from 2001 to 2003, when he was a member of the Texas Rangers.

In a statement several hours after the report emerged, Rodriguez denied that he had any relationship with the director of the clinic, Anthony Bosch, or that he was ever treated by him.

The statement, issued through a public-relations firm, said: “The news report about a purported relationship between Alex Rodriguez and Anthony Bosch are not true. Alex Rodriguez was not Mr. Bosch’s patient, he was never treated by him and he was never advised by him. The purported documents referenced in the story — at least as they relate to Alex Rodriguez — are not legitimate.”

Gonzalez also issued a denial, through Twitter, stating: “I’ve never used performance-enhancing drugs of any kind and I never will. I’ve never met or spoke with Tony Bosch or used any substance.”

The Yankees, meanwhile, said that they fully supported baseball’s drug program and that they would have no further comment until an investigation by the commissioner’s office had concluded.

Although Rodriguez has denied using performance enhancers after 2003, investigators for Major League Baseball have questioned him several times in recent years about possible drug links and in each instance he has maintained his stance. According to two people in baseball, the investigators now now plan to question him again, along with the others cited in the Miami New Times report.

Until now, Major League Baseball did not have any documents that linked players using the clinic to performance-enhancers. The investigators, the two people said, will now seek to obtain the records cited by Miami New Times and authenticate them in the hopes of using them as evidence to discipline the players.

Unlike the federal government, baseball’s investigators do not have the power to subpoena documents to compel witnesses to talk to them. They hope to talk to Bosch but have not yet attempted to do so. Their hope is that federal investigators of the clinic, will be able to obtain records and testimony that will ultimately help baseball determine what disciplianary measures may be called for.

Baseball first became aware of the clinic in 2009 when its investigators uncovered evidence that the slugger Manny Ramirez had received a banned drug from the facility. Ramirez was ultimately suspended 50 games for that infraction.

Last summer, the investigators began to take another look at the clinic as they investigated Cabrera after he tested positive. In the course of that investigation they uncovered evidence that an employee for Cabrera’s agents, Sam and Seth Levinson, had hatched a cover-up scheme to deceive a baseball arbitrator and have the suspension for the positive drug test thrown out.

Baseball officials were angered by the attempt to subvert their drug-testing program and began their own investigation of the employee, Juan Nunez, and the Levinsons. In doing so, the two people said, they uncovered the links between players and the clinic. The officials did not believe that Nunez acted alone and asked the players union, which certifies player agents, to conduct its own investigation.

According to one baseball official, six of the players the commissioner’s office believes were treated by the clinic are clients of the Levinsons.

Rodriguez is not, but the 37-year-old third baseman will undoubtedly become the focal point of the case. He is not expected to return to action from his surgery until July, when he will turn 38. He has become increasingly brittle midway through a 10-year, $275 million contract that has become a burden to the Yankees, and his link to the medical records, if true, will only raise more questions about his future.

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China may consider ending its decade-long ban on video game consoles

Shares of Sony (SNE) and Nintendo (NTDOY) surged on Monday following a report from China’s official newspaper that claimed the country is considering the lift of a decade-long ban on video game consoles. An unnamed source told the China Daily newspaper that the Ministry of Culture is “reviewing the policy,” and has conducted surveys and held discussions with other ministries on the possibility of lifting the ban. An official at the ministry’s cultural market department denied the report in a statement to Reuters, however, claiming it “is not considering lifting the ban.”

[More from BGR: BlackBerry 10 debuts on Wednesday – strap in for a wild ride]

China banned the sale of video game consoles in 2000 to safeguard children’s mental and physical development. In order for the ban to be lifted, the seven different ministries who issued the ruling must all agree to reverse it.

[More from BGR: Apple releases iOS 6.1 to iPhone, iPad and iPod touch users]

Shares of Sony’s stock were up more than 8% in Tokyo on Monday, while Nintendo gained 3.5% on a weaker Nikkei index.

This article was originally published on BGR.com

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Dior: Jennifer Lawrence dress had no malfunction

LOS ANGELES (AP) — That was no wardrobe malfunction — that was couture.

When Jennifer Lawrence ascended the stairs to accept her SAG Award Sunday night, a bit of skin showed through the skirt of her gown, leading to some speculation that it had ripped.

Dior Couture told The Associated Press that wasn't so.

The design house said Lawrence's gown was designed by Raf Simons "with different levels of tulle and satin." That was what viewers saw on television when she lifted her gown to walk upstairs.

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Streaming Shakes Up Music Industry’s Model for Royalties

Jim Wilson/The New York Times

Zoe Keating published on her blog the details of what she made in royalties from the Web streaming of her music. It wasn’t a lot.

Like plenty of music fans, Sam Broe jumped at the chance to join Spotify two summers ago, and he hasn’t looked back.

Spotify, which began streaming music in Sweden in 2008, lets users choose from millions of songs over the Internet free or by subscription, and is increasingly seen as representing the future of music consumption. Mr. Broe, a 26-year-old from Brooklyn, said that having all that music at his fingertips helped him trim his monthly music budget from $30 to the $10 fee he pays for Spotify’s premium service.

“The only time I download anything on iTunes is in the rare case that I can’t find it on Spotify,” he said.

A decade after Apple revolutionized the music world with its iTunes store, the music industry is undergoing another, even more radical, digital transformation as listeners begin to move from CDs and downloads to streaming services like Spotify, Pandora and YouTube.

As purveyors of legally licensed music, they have been largely welcomed by an industry still buffeted by piracy. But as the companies behind these digital services swell into multibillion-dollar enterprises, the relative trickle of money that has made its way to artists is causing anxiety at every level of the business.

Late last year, Zoe Keating, an independent musician from Northern California, provided an unusually detailed case in point. In voluminous spreadsheets posted to her Tumblr blog, she revealed the royalties she gets from various services, down to the ten-thousandth of a cent.

Even for an under-the-radar artist like Ms. Keating, who describes her style as “avant cello,” the numbers painted a stark picture of what it is like to be a working musician these days. After her songs had been played more than 1.5 million times on Pandora over six months, she earned $1,652.74. On Spotify, 131,000 plays last year netted just $547.71, or an average of 0.42 cent a play.

“In certain types of music, like classical or jazz, we are condemning them to poverty if this is going to be the only way people consume music,” Ms. Keating said.

The way streaming services pay royalties represents a major shift in the economic gears that have been underlying the industry for decades.

From 78 r.p.m. records to the age of iTunes, artists’ record royalties have been counted as a percentage of a sale price. On a 99-cent download, a typical artist may earn 7 to 10 cents after deductions for the retailer, the record company and the songwriter, music executives say. One industry joke calls the flow of these royalties a “river of nickels.”

In the new economics of streaming music, however, the river of nickels looks more like a torrent of micropennies.

Spotify, Pandora and others like them pay fractions of a cent to record companies and publishers each time a song is played, some portion of which goes to performers and songwriters as royalties. Unlike the royalties from a sale, these payments accrue every time a listener clicks on a song, year after year.

The question dogging the music industry is whether these micropayments can add up to anything substantial.

“No artist will be able to survive to be professionals except those who have a significant live business, and that’s very few,” said Hartwig Masuch, chief executive of BMG Rights Management.

Spotify has 20 million users in 17 countries, with five million of them paying $5 to $10 a month to eliminate the ads seen by freeloaders.

In a recent interview, Sean Parker, a board member, said he believed Spotify would eventually attract enough subscribers to help return the music industry to its former glory — that is, to the days before Mr. Parker’s first major enterprise, Napster, came along.

“I believe that Spotify is the company that will make it succeed,” said Mr. Parker, who is also a former president of Facebook. “It’s the right model if you want to build the pot of money back up to where it was in the late ’90s, when the industry was at its peak. This is the only model that’s going to get you there.”

This article has been revised to reflect the following correction:

Correction: January 29, 2013

An earlier version of this article gave an incorrect estimate of the potential earnings of a song on Spotify’s paid tier. According to a number of music executives, Spotify generally pays 0.5 to 0.7 cent a stream for the paid tier, which results in $5,000 to $7,000 per million plays, not $5,000 to $8,000.

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